Oocyte-Specific Deletion of <i>Slc6a9</i> Encoding the GLYT1 Glycine Transporter Eliminates Glycine Transport in Mouse Preimplantation Embryos and Their Ability to Counter Hypertonic Stress

Oocyte-Specific Deletion of <i>Slc6a9</i> Encoding the GLYT1 Glycine Transporter Eliminates Glycine Transport in Mouse Preimplantation Embryos and Their Ability to Counter Hypertonic Stress

Early preimplantation mouse embryos are sensitive to increased osmolarity, which can block their development. To overcome this, they accumulate organic osmolytes to maintain cell volume. The main organic osmolyte used by early mouse embryos is glycine. Glycine is transported during the mature egg an...

Full description

Bibliographic Details
Main Authors: Allison K. Tscherner, Taylor McClatchie, Gracia Kaboba, Detlev Boison, Jay M. Baltz
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Cells
Subjects:
oocyte
preimplantation embryo
glycine
transport
cell volume
knockout
Online Access:https://www.mdpi.com/2073-4409/12/20/2500

Internet

https://www.mdpi.com/2073-4409/12/20/2500

Similar Items