DNA polymerases in precise and predictable CRISPR/Cas9-mediated chromosomal rearrangements

DNA polymerases in precise and predictable CRISPR/Cas9-mediated chromosomal rearrangements

Abstract Background Recent studies have shown that, owning to its cohesive cleavage, Cas9-mediated CRISPR gene editing outcomes at junctions of chromosomal rearrangements or DNA-fragment editing are precise and predictable; however, the underlying mechanisms are poorly understood due to lack of suit...

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Bibliographic Details
Main Authors: Mohammadreza M. Mehryar, Xin Shi, Jingwei Li, Qiang Wu
Format: Article
Language:English
Published: BMC 2023-12-01
Series:BMC Biology
Subjects:
Gene editing
CRISPR/Cas9
DNA-fragment editing
DNA polymerase
PolQ
PolL
Online Access:https://doi.org/10.1186/s12915-023-01784-y

Internet

https://doi.org/10.1186/s12915-023-01784-y

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