Controlled synthesis and structure characterization of a new fluconazole polymorph using analytical techniques and multivariate method

Controlled synthesis and structure characterization of a new fluconazole polymorph using analytical techniques and multivariate method

In the crystallization and search for higher multicomponent forms of fluconazole (FLZ), a metastable FLZ polymorph (concomitant) that manifests in the same crystallization system and transforms into the stable FLZ form (II) after the lyophilization process was observed. In this report, we demonstrat...

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Bibliographic Details
Main Authors: Bolaji C. Dayo Owoyemi, Cecilia C.P. da Silva, Amos O. Akinyemi, Banky O. Amuwaolorun, Roxana Lili Roque-Flores, Gabriel Lima Barros de Araújo, Javier Ellena, Renato L. Carneiro
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Scientific African
Subjects:
Fluconazole
Polymorphs
Raman/FT-IR spectroscopy
PCA
XRD
Solubility
Online Access:http://www.sciencedirect.com/science/article/pii/S2468227623004830

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http://www.sciencedirect.com/science/article/pii/S2468227623004830

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