Inhibition of kidney proximal tubular glucose reabsorption does not prevent against diabetic nephropathy in type 1 diabetic eNOS knockout mice.

Inhibition of kidney proximal tubular glucose reabsorption does not prevent against diabetic nephropathy in type 1 diabetic eNOS knockout mice.

BACKGROUND AND OBJECTIVE: Sodium glucose cotransporter 2 (SGLT2) is the main luminal glucose transporter in the kidney. SGLT2 inhibition results in glycosuria and improved glycaemic control. Drugs inhibiting this transporter have recently been approved for clinical use and have been suggested to hav...

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Bibliographic Details
Main Authors: Muralikrishna Gangadharan Komala, Simon Gross, Harshini Mudaliar, Chunling Huang, Katherine Pegg, Amanda Mather, Sylvie Shen, Carol A Pollock, Usha Panchapakesan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4219667?pdf=render

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http://europepmc.org/articles/PMC4219667?pdf=render

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