Broadening the spectrum of ivermectin: Its effect on Trypanosoma cruzi and related trypanosomatids

Broadening the spectrum of ivermectin: Its effect on Trypanosoma cruzi and related trypanosomatids

Chagas disease is an endemic American parasitosis, caused by Trypanosoma cruzi. The current therapies, benznidazole (BZN) and nifurtimox (NFX), show limited efficacy and multiple side effects. Thus, there is a need to develop new trypanocidal strategies. Ivermectin (IVM) is a broad-spectrum antipara...

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Bibliographic Details
Main Authors: Laura Fraccaroli, María Daniela Ruiz, Virginia Gabriela Perdomo, Agustina Nicole Clausi, Darío Emmanuel Balcazar, Luciana Larocca, Carolina Carrillo
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Chagas disease
ivermectin
drug repurposing
trypanocidal drug
drug combination
Trypanosoma cruzi
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2022.885268/full

Internet

https://www.frontiersin.org/articles/10.3389/fcimb.2022.885268/full

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