Macrophage-Derived Factors with the Potential to Contribute to Pathogenicity of HIV-1 and HIV-2: Role of CCL-2/MCP-1

Macrophage-Derived Factors with the Potential to Contribute to Pathogenicity of HIV-1 and HIV-2: Role of CCL-2/MCP-1

Human immunodeficiency virus type 2 (HIV-2) is known to be less pathogenic than HIV-1. However, the mechanism(s) underlying the decreased HIV-2 pathogenicity is not fully understood. Herein, we report that β-chemokine CCL2 expression was increased in HIV-1-infected human monocyte-derived macrophages...

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Bibliographic Details
Main Authors: Chunling Gao, Weiming Ouyang, Joseph Kutza, Tobias A. Grimm, Karen Fields, Carla S. R. Lankford, Franziska Schwartzkopff, Mark Paciga, Tzanko Stantchev, Linda Tiffany, Klaus Strebel, Kathleen A. Clouse
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Viruses
Subjects:
HIV-1
HIV-2
CCL2
STAT1
macrophage
CULLIN 2
Online Access:https://www.mdpi.com/1999-4915/15/11/2160

Internet

https://www.mdpi.com/1999-4915/15/11/2160

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