The Increase in the Drug Resistance of Acute Myeloid Leukemia THP-1 Cells in High-Density Cell Culture Is Associated with Inflammatory-like Activation and Anti-Apoptotic Bcl-2 Proteins

The Increase in the Drug Resistance of Acute Myeloid Leukemia THP-1 Cells in High-Density Cell Culture Is Associated with Inflammatory-like Activation and Anti-Apoptotic Bcl-2 Proteins

It is known that cell culture density can modulate the drug resistance of acute myeloid leukemia (AML) cells. In this work, we studied the drug sensitivity of AML cells in high-density cell cultures (cell lines THP-1, HL-60, MV4-11, and U937). It was shown that the AML cells in high-density cell cul...

Full description

Bibliographic Details
Main Authors: Margarita Kobyakova, Yana Lomovskaya, Anatoly Senotov, Alexey Lomovsky, Vladislav Minaychev, Irina Fadeeva, Daria Shtatnova, Kirill Krasnov, Alena Zvyagina, Irina Odinokova, Vladimir Akatov, Roman Fadeev
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:International Journal of Molecular Sciences
Subjects:
acute myeloid leukemia
drug resistance
DNA-damaging drugs
izTRAIL
inflammation
high-density cell culture
Online Access:https://www.mdpi.com/1422-0067/23/14/7881

Internet

https://www.mdpi.com/1422-0067/23/14/7881

Similar Items