Dopamine signaling enriched striatal gene set predicts striatal dopamine synthesis and physiological activity in vivo

Dopamine signaling enriched striatal gene set predicts striatal dopamine synthesis and physiological activity in vivo

Abstract The polygenic architecture of schizophrenia implicates several molecular pathways involved in synaptic function. However, it is unclear how polygenic risk funnels through these pathways to translate into syndromic illness. Using tensor decomposition, we analyze gene co-expression in the cau...

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Main Authors: Leonardo Sportelli, Daniel P. Eisenberg, Roberta Passiatore, Enrico D’Ambrosio, Linda A. Antonucci, Jasmine S. Bettina, Qiang Chen, Aaron L. Goldman, Michael D. Gregory, Kira Griffiths, Thomas M. Hyde, Joel E. Kleinman, Antonio F. Pardiñas, Madhur Parihar, Teresa Popolizio, Antonio Rampino, Joo Heon Shin, Mattia Veronese, William S. Ulrich, Caroline F. Zink, Alessandro Bertolino, Oliver D. Howes, Karen F. Berman, Daniel R. Weinberger, Giulio Pergola
Format: Article
Language:English
Published: Nature Portfolio 2024-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-47456-5

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https://doi.org/10.1038/s41467-024-47456-5

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