Single-Cell Transcriptomic Analysis of Tumor-Derived Fibroblasts and Normal Tissue-Resident Fibroblasts Reveals Fibroblast Heterogeneity in Breast Cancer

Single-Cell Transcriptomic Analysis of Tumor-Derived Fibroblasts and Normal Tissue-Resident Fibroblasts Reveals Fibroblast Heterogeneity in Breast Cancer

Cancer-associated fibroblasts (CAFs) are a prominent stromal cell type in solid tumors and molecules secreted by CAFs play an important role in tumor progression and metastasis. CAFs coexist as heterogeneous populations with potentially different biological functions. Although CAFs are a major compo...

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Bibliographic Details
Main Authors: Aimy Sebastian, Nicholas R. Hum, Kelly A. Martin, Sean F. Gilmore, Ivana Peran, Stephen W. Byers, Elizabeth K. Wheeler, Matthew A. Coleman, Gabriela G. Loots
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Cancers
Subjects:
cancer-associated fibroblasts
breast cancer
mammary fat pad
gene expression profiling
scRNA-seq
CAF heterogeneity
Online Access:https://www.mdpi.com/2072-6694/12/5/1307

Internet

https://www.mdpi.com/2072-6694/12/5/1307

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