The B56γ3-containing protein phosphatase 2A attenuates p70S6K-mediated negative feedback loop to enhance AKT-facilitated epithelial-mesenchymal transition in colorectal cancer

The B56γ3-containing protein phosphatase 2A attenuates p70S6K-mediated negative feedback loop to enhance AKT-facilitated epithelial-mesenchymal transition in colorectal cancer

Abstract Background Protein phosphatase 2A (PP2A) is one of the major protein phosphatases in eukaryotic cells and is essential for cellular homeostasis. PP2A is a heterotrimer comprising the dimeric AC core enzyme and a highly variable regulatory B subunit. Distinct B subunits help the core enzyme...

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Bibliographic Details
Main Authors: Kai-Ching Hsiao, Siou-Ying Ruan, Shih-Min Chen, Tai-Yu Lai, Ren-Hao Chan, Yan-Ming Zhang, Chien-An Chu, Hung-Chi Cheng, Hung-Wen Tsai, Yi-Fang Tu, Brian K. Law, Ting-Tsung Chang, Nan-Haw Chow, Chi-Wu Chiang
Format: Article
Language:English
Published: BMC 2023-07-01
Series:Cell Communication and Signaling
Subjects:
AKT
B56γ3
Colorectal cancer
EMT
PP2A
p70S6K
Online Access:https://doi.org/10.1186/s12964-023-01182-5

Internet

https://doi.org/10.1186/s12964-023-01182-5

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