A Robust FISH Assay to Detect FGFR2 Translocations in Intrahepatic Cholangiocarcinoma Patients

A Robust FISH Assay to Detect FGFR2 Translocations in Intrahepatic Cholangiocarcinoma Patients

FGFR fusions retaining the FGFR kinase domain are active kinases that are either overexpressed or constitutively activated throughout diverse cancer types. The presence of FGFR translocations enhances tumor cell proliferation and contributes to significant sensitivity to FGFR kinase inhibitors. FGFR...

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Bibliographic Details
Main Authors: Lei Zhang, Hao Zheng, Linyu Xu, Si You, Yuanyuan Shen, Yang Han, Steve Anderson
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Diagnostics
Subjects:
FGFR2 translocation
intrahepatic cholangiocarcinoma
break-apart FISH
biallelic translocation
Online Access:https://www.mdpi.com/2075-4418/13/12/2088

Internet

https://www.mdpi.com/2075-4418/13/12/2088

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