Multicellular tumor spheroid model to evaluate spatio-temporal dynamics effect of chemotherapeutics: application to the gemcitabine/CHK1 inhibitor combination in pancreatic cancer

Multicellular tumor spheroid model to evaluate spatio-temporal dynamics effect of chemotherapeutics: application to the gemcitabine/CHK1 inhibitor combination in pancreatic cancer

<p>Abstract</p> <p>Background</p> <p>The multicellular tumor spheroid (MCTS) is an in vitro model associating malignant-cell microenvironment and 3D organization as currently observed in avascular tumors.</p> <p>Methods</p> <p>In order to evaluat...

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Bibliographic Details
Main Authors: Dufau Isabelle, Frongia Céline, Sicard Flavie, Dedieu Laure, Cordelier Pierre, Ausseil Frédéric, Ducommun Bernard, Valette Annie
Format: Article
Language:English
Published: BMC 2012-01-01
Series:BMC Cancer
Subjects:
Tumor spheroid
Combination
Gemcitabine
CHK1 inhibitor
Pancreatic cancer
Online Access:http://www.biomedcentral.com/1471-2407/12/15

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http://www.biomedcentral.com/1471-2407/12/15

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