Knockout of B2M in combination with PD-L1 overexpression protects MSC-derived new islet β cells from graft rejection in the treatment of canine diabetes mellitus

Knockout of B2M in combination with PD-L1 overexpression protects MSC-derived new islet β cells from graft rejection in the treatment of canine diabetes mellitus

Abstract Background The immunogenicity of allogeneic mesenchymal stem cells (MSCs) is significantly enhanced after transplantation or differentiation, and these cells can be recognized and cleared by recipient immune cells. Graft rejection has become a major obstacle to improving the therapeutic eff...

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Bibliographic Details
Main Authors: Pengxiu Dai, Yi Wu, Qingjie Du, Juanjuan Du, Keyi Wang, Ruiqi Chen, Xiancheng Feng, Chen Chen, Xinke Zhang
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Stem Cell Research & Therapy
Subjects:
Gene-edited ADSCs
Immunogenicity
New islet β cells
Antigraft rejection
Therapeutic effect
Online Access:https://doi.org/10.1186/s13287-024-04067-7

Internet

https://doi.org/10.1186/s13287-024-04067-7

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