Targeting connexin 43 provides anti-inflammatory effects after intracerebral hemorrhage injury by regulating YAP signaling

Targeting connexin 43 provides anti-inflammatory effects after intracerebral hemorrhage injury by regulating YAP signaling

Abstract Background In the central nervous system (CNS), connexin 43 (Cx43) is mainly expressed in astrocytes and regulates astrocytic network homeostasis. Similar to Cx43 overexpression, abnormal excessive opening of Cx43 hemichannels (Cx43Hcs) on reactive astrocytes aggravates the inflammatory res...

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Bibliographic Details
Main Authors: Hailong Yu, Xiang Cao, Wei Li, Pinyi Liu, Yuanyuan Zhao, Lilong Song, Jian Chen, Beilei Chen, Wenkui Yu, Yun Xu
Format: Article
Language:English
Published: BMC 2020-10-01
Series:Journal of Neuroinflammation
Subjects:
Intracerebral hemorrhage injury
Connexin 43
Hemichannels
Reactive astrocyte
YAP
Online Access:http://link.springer.com/article/10.1186/s12974-020-01978-z

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http://link.springer.com/article/10.1186/s12974-020-01978-z

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