Liquid chromatography-tandem mass spectrometry analysis of a ratio-optimized drug pair of Sophora flavescens Aiton and Coptis chinensis Franch and study on the mechanism of anti-colorectal cancer effect of two alkaloids thereof

Liquid chromatography-tandem mass spectrometry analysis of a ratio-optimized drug pair of Sophora flavescens Aiton and Coptis chinensis Franch and study on the mechanism of anti-colorectal cancer effect of two alkaloids thereof

The drug pair consisting of Sophora flavescens Aiton (Sophorae flavescentis radix, Kushen) and Coptis chinensis Franch. (Coptidis rhizoma, Huanglian), as described in Prescriptions for Universal Relief (Pujifang), is widely used to treat laxation. Matrine and berberine are the major active component...

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Bibliographic Details
Main Authors: Zihan Chen, Yingying Dong, Qiuying Yan, Qin Li, Chengtao Yu, Yueyang Lai, Jiani Tan, Minmin Fan, Changliang Xu, Liu Li, Weixing Shen, Junfei Gu, Haibo Cheng, Dongdong Sun
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Oncology
Subjects:
Sophora flavescens Aiton
Coptis chinensis Franch
matrine
berberine
colorectal cancer
intestinal microbiota
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1198467/full

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https://www.frontiersin.org/articles/10.3389/fonc.2023.1198467/full

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