Structure and mutation of deoxypodophyllotoxin synthase (DPS) from Podophyllum hexandrum
Deoxypodophyllotoxin synthase (DPS) is a 2-oxoglutarate (2-OG) dependent non-heme iron (II) dioxygenase that catalyzes the stereoselective ring-closing carbon-carbon bond formation of deoxypodophyllotoxin from the aryllignan (−)-yatein. Deoxypodophyllotoxin is a precursor of topoisomerase II inhibit...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-05-01
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| Series: | Frontiers in Catalysis |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fctls.2023.1178345/full |