Genome-wide interrogation of structural variation reveals novel African-specific prostate cancer oncogenic drivers

Genome-wide interrogation of structural variation reveals novel African-specific prostate cancer oncogenic drivers

Abstract Background African ancestry is a significant risk factor for advanced prostate cancer (PCa). Mortality rates in sub-Saharan Africa are 2.5-fold greater than global averages. However, the region has largely been excluded from the benefits of whole genome interrogation studies. Additionally,...

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Bibliographic Details
Main Authors: Tingting Gong, Weerachai Jaratlerdsiri, Jue Jiang, Cali Willet, Tracy Chew, Sean M. Patrick, Ruth J. Lyons, Anne-Maree Haynes, Gabriela Pasqualim, Ilma Simoni Brum, Phillip D. Stricker, Shingai B. A. Mutambirwa, Rosemarie Sadsad, Anthony T. Papenfuss, Riana M. S. Bornman, Eva K. F. Chan, Vanessa M. Hayes
Format: Article
Language:English
Published: BMC 2022-08-01
Series:Genome Medicine
Subjects:
Chromosomal instability
Prostate cancer
African ancestry
Advanced disease
Ethnic disparity
Whole genome sequencing
Online Access:https://doi.org/10.1186/s13073-022-01096-w

Internet

https://doi.org/10.1186/s13073-022-01096-w

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