GAS6-based CAR-T cells exhibit potent antitumor activity against pancreatic cancer

GAS6-based CAR-T cells exhibit potent antitumor activity against pancreatic cancer

Abstract Background The receptor tyrosine kinases TAM family (TYRO3, AXL, and MERTK) are highly expressed in multiple forms of cancer cells and tumor-associated macrophages and promote the development of cancers including pancreatic tumor. Targeting TAM receptors could be a promising therapeutic opt...

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Bibliographic Details
Main Authors: Jiawei Fan, Ye Yu, Lanzhen Yan, Yuncang Yuan, Bin Sun, Dong Yang, Nan Liu, Jing Guo, Jie Zhang, Xudong Zhao
Format: Article
Language:English
Published: BMC 2023-07-01
Series:Journal of Hematology & Oncology
Subjects:
CAR-T-cell therapy
TAM family
GAS6
Pancreatic cancer
Online Access:https://doi.org/10.1186/s13045-023-01467-9

Internet

https://doi.org/10.1186/s13045-023-01467-9

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