(–)-Epicatechin Suppresses Angiotensin II-induced Cardiac Hypertrophy via the Activation of the SP1/SIRT1 Signaling Pathway

(–)-Epicatechin Suppresses Angiotensin II-induced Cardiac Hypertrophy via the Activation of the SP1/SIRT1 Signaling Pathway

Background/Aims: Flavonol (–)-epicatechin (EPI) is present in high amounts in cocoa and tea products, and has been shown to exert beneficial effects on the cardiovascular system. However, the precise mechanism of EPI on cardiomyocyte hypertrophy has not yet been determined. In this study, we examine...

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Bibliographic Details
Main Authors: Zeng-xiang Dong, Lin Wan, Ren-jun Wang, Yuan-qi Shi, Guang-zhong Liu, Si-jia Zheng, Hui-ling Hou, Wei Han, Xin Hai
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2017-04-01
Series:Cellular Physiology and Biochemistry
Subjects:
Epicatechin
Angiotensin II
Cardiac hypertrophy
SP1
SIRT1
Online Access:http://www.karger.com/Article/FullText/475396

Internet

http://www.karger.com/Article/FullText/475396

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