Roxadustat (FG-4592) abated lipopolysaccharides-induced depressive-like symptoms via PI3K signaling

Roxadustat (FG-4592) abated lipopolysaccharides-induced depressive-like symptoms via PI3K signaling

BackgroundDespite its role in inflammation and the redox system under hypoxia, the effects and molecular mechanisms of hypoxia-inducible factor (HIF) in neuroinflammation-associated depression are poorly explored. Furthermore, Prolyl hydroxylase domain-containing proteins (PHDs) regulate HIF-1; howe...

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Bibliographic Details
Main Authors: Axiang Li, Zizhen Liu, Tahir Ali, Ruyan Gao, Yanhua Luo, Qichao Gong, Chenyou Zheng, Weifen Li, Hongling Guo, Xinshe Liu, Shupeng Li, Tao Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Molecular Neuroscience
Subjects:
lipopolysaccharides
depression
Neuroinflammation
HIF-PHD/PI3K
roxadustat (FG-4592)
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2023.1048985/full

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https://www.frontiersin.org/articles/10.3389/fnmol.2023.1048985/full

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