Autotaxin and LPA receptors represent potential molecular targets for the radiosensitization of murine glioma through effects on tumor vasculature.

Autotaxin and LPA receptors represent potential molecular targets for the radiosensitization of murine glioma through effects on tumor vasculature.

Despite wide margins and high dose irradiation, unresectable malignant glioma (MG) is less responsive to radiation and is uniformly fatal. We previously found that cytosolic phospholipase A2 (cPLA(2)) is a molecular target for radiosensitizing cancer through the vascular endothelium. Autotaxin (ATX)...

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Bibliographic Details
Main Authors: Stephen M Schleicher, Dinesh K Thotala, Amanda G Linkous, Rong Hu, Kathleen M Leahy, Eugenia M Yazlovitskaya, Dennis E Hallahan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3140496?pdf=render

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http://europepmc.org/articles/PMC3140496?pdf=render

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