G4-binding drugs, chlorpromazine and prochlorperazine, repurposed against COVID-19 infection in hamsters

G4-binding drugs, chlorpromazine and prochlorperazine, repurposed against COVID-19 infection in hamsters

The COVID-19 pandemic caused by SARS-CoV-2 has caused millions of infections and deaths worldwide. Limited treatment options and the threat from emerging variants underline the need for novel and widely accessible therapeutics. G-quadruplexes (G4s) are nucleic acid secondary structures known to affe...

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Bibliographic Details
Main Authors: Shuvra Shekhar Roy, Shalu Sharma, Zaigham Abbas Rizvi, Dipanjali Sinha, Divya Gupta, Mercy Rophina, Paras Sehgal, Srikanth Sadhu, Manas Ranjan Tripathy, Sweety Samal, Souvik Maiti, Vinod Scaria, Sridhar Sivasubbu, Amit Awasthi, Krishnan H. Harshan, Sanjeev Jain, Shantanu Chowdhury
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Molecular Biosciences
Subjects:
RNA G-quadruplex
FDA-approved drugs
G-quadruplex binding drugs
hamster model of COVID-19
Conserved motif
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2023.1133123/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2023.1133123/full

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