Upregulation of IFNɣ-mediated chemokines dominate the immune transcriptome of muscle-invasive urothelial carcinoma

Abstract Tumor inflammation is prognostically significant in high-grade muscle-invasive bladder cancer (MIBC). However, the underlying mechanisms remain elusive. To identify inflammation-associated immune gene expression patterns, we performed transcriptomic profiling of 40 MIBC archival tumors usin...

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Bibliographic Details
Main Authors: Ekaterina Olkhov-Mitsel, Anjelica Hodgson, Stan K. Liu, Danny Vesprini, Jane Bayani, John M. S. Bartlett, Bin Xu, Michelle R. Downes
Format: Article
Language:English
Published: Nature Portfolio 2022-01-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-04678-7