Cyclin-dependent kinase five mediates activation of lung xanthine oxidoreductase in response to hypoxia.

Xanthine oxidoreductase (XOR) is involved in oxidative metabolism of purines and is a source of reactive oxygen species (ROS). As such, XOR has been implicated in oxidant-mediated injury in multiple cardiopulmonary diseases. XOR enzyme activity is regulated, in part, via a phosphorylation-dependent,...

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Bibliographic Details
Main Authors: Bo S Kim, Leonid Serebreni, Jonathan Fallica, Omar Hamdan, Lan Wang, Laura Johnston, Todd Kolb, Mahendra Damarla, Rachel Damico, Paul M Hassoun
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4382197?pdf=render