GCN2 upregulates autophagy in response to short-term deprivation of a single essential amino acid

GCN2 upregulates autophagy in response to short-term deprivation of a single essential amino acid

The ability to adapt the proteolysis rates based on fluctuations in essential amino acid (EAA) availability is essential for life. The GCN2-eIF2α-ATF4 signaling pathway is involved in the adaptive response to EAA deprivations. Our previous results demonstrated that activation of this pathway is invo...

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Bibliographic Details
Main Authors: Anne-Catherine Maurin, Laurent Parry, Wafa B’chir, Valérie Carraro, Cécile Coudy-Gandilhon, Ghita Chaouki, Cédric Chaveroux, Sylvie Mordier, Brigitte Martinie, Vanessa Reinhardt, Céline Jousse, Alain Bruhat, Patrice Codogno, Julien Averous, Pierre Fafournoux
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:Autophagy Reports
Subjects:
atf4
eif2α
leucine
lysine
Online Access:http://dx.doi.org/10.1080/27694127.2022.2049045

Internet

http://dx.doi.org/10.1080/27694127.2022.2049045

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