The microbial genotoxin colibactin exacerbates mismatch repair mutations in colorectal tumors

The microbial genotoxin colibactin exacerbates mismatch repair mutations in colorectal tumors

Certain Enterobacteriaceae strains contain a 54-kb biosynthetic gene cluster referred to as “pks” encoding the biosynthesis of a secondary metabolite, colibactin. Colibactin-producing E. coli promote colorectal cancer (CRC) in preclinical models, and in vitro induce a specific mutational signature t...

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Bibliographic Details
Main Authors: Michael W. Dougherty, Rafael Valdés-Mas, Kevin M. Wernke, Raad Z. Gharaibeh, Ye Yang, Jason O. Brant, Alberto Riva, Marcus Muehlbauer, Eran Elinav, Jens Puschhof, Seth B. Herzon, Christian Jobin
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Colibactin
Escherichia coli
Mutation
Colorectal cancer
Mismatch repair
Online Access:http://www.sciencedirect.com/science/article/pii/S147655862300043X

Internet

http://www.sciencedirect.com/science/article/pii/S147655862300043X

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