Losartan improves intestinal mucositis induced by 5-fluorouracil in mice

Losartan improves intestinal mucositis induced by 5-fluorouracil in mice

Abstract Intestinal mucositis (IM) is a common side effect of 5-fluorouracil (5-FU)-based chemotherapy, which negatively impacts therapeutic outcomes and delays subsequent cycles of chemotherapy resulting in dose reductions and treatment discontinuation. In search of new pharmacological alternatives...

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Bibliographic Details
Main Authors: Maisie Mitchele Barbosa Oliveira, Aurigena Antunes de Araújo, Susana Barbosa Ribeiro, Polyana Crislayne Moreira de Sales Mota, Vitória Barros Marques, Conceição da Silva Martins Rebouças, Jozi Godoy Figueiredo, Patrícia Batista Barra, Gerly Anne de Castro Brito, Renata Ferreira de Carvalho Leitão, Gerlane Coelho Bernardo Guerra, Caroline Addison Carvalho Xavier de Medeiros
Format: Article
Language:English
Published: Nature Portfolio 2021-12-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-01969-x

Internet

https://doi.org/10.1038/s41598-021-01969-x

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