Loss of the melanocortin-4 receptor in mice causes dilated cardiomyopathy

Loss of the melanocortin-4 receptor in mice causes dilated cardiomyopathy

Haploinsufficiency of the melanocortin-4 receptor, the most common monogenetic obesity syndrome in humans, is associated with a reduction in autonomic tone, bradycardia, and incidence of obesity-associated hypertension. Thus, it has been assumed that melanocortin obesity syndrome may be protective w...

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Bibliographic Details
Main Authors: Michael J Litt, G Donald Okoye, Daniel Lark, Isin Cakir, Christy Moore, Mary C Barber, James Atkinson, Josh Fessel, Javid Moslehi, Roger D Cone
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-08-01
Series:eLife
Subjects:
heart
cardiovascular
cardiomyopathy
MC4R
melanocortin-4 receptor
obesity
Online Access:https://elifesciences.org/articles/28118

Internet

https://elifesciences.org/articles/28118

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