Readthrough isoform of aquaporin-4 (AQP4) as a therapeutic target for Alzheimer’s disease and other proteinopathies

Readthrough isoform of aquaporin-4 (AQP4) as a therapeutic target for Alzheimer’s disease and other proteinopathies

Abstract The glymphatic system is a crucial component in preserving brain homeostasis by facilitating waste clearance from the central nervous system (CNS). Aquaporin-4 (AQP4) water channels facilitate the continuous interchange between cerebrospinal fluid and brain interstitial fluid by convective...

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Bibliographic Details
Main Authors: Pablo Mohaupt, Jérôme Vialaret, Christophe Hirtz, Sylvain Lehmann
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Alzheimer’s Research & Therapy
Subjects:
Aquaporin-4
Waste clearance
Proteinopathies
Alzheimer’s
Protein aggregation
Therapeutic target
Online Access:https://doi.org/10.1186/s13195-023-01318-2

Internet

https://doi.org/10.1186/s13195-023-01318-2

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