Humanized mice generated by intra-bone marrow injection of CD133-positive hematopoietic stem cells: application to HIV-1 research

Humanized mice generated by intra-bone marrow injection of CD133-positive hematopoietic stem cells: application to HIV-1 research

Animal models are essential for basic and clinical research on virus diseases. Humanized mice (mice reconstituted with human hematopoietic cells) have been effectively used for various virus studies as small animal models. Studies on human-tropic HIV-1 have also been performed using different humani...

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Bibliographic Details
Main Authors: Takaaki Koma, Tokifumi Odaka, Sung-Il Lee, Naoya Doi, Tomoyuki Kondo, Kazu Okuma, Jun-Ichi Fujisawa, Akio Adachi, Masako Nomaguchi
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Virology
Subjects:
HIV-1
humanized mouse
CD133
IBMI
X4-tropic
R5-tropic
Online Access:https://www.frontiersin.org/articles/10.3389/fviro.2023.1192184/full

Internet

https://www.frontiersin.org/articles/10.3389/fviro.2023.1192184/full

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