PACAP and VIP inhibit the invasiveness of glioblastoma cells exposed to hypoxia through the regulation of HIFs and EGFR expression

PACAP and VIP inhibit the invasiveness of glioblastoma cells exposed to hypoxia through the regulation of HIFs and EGFR expression

Pituitary adenylate cyclase-activating polypeptide (PACAP) and vasoactive intestinal peptide (VIP) through the binding of vasoactive intestinal peptide receptors (VIPRs), perform a wide variety of effects in human cancers, including glioblastoma multiforme (GBM). This tumor is characterized by exten...

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Bibliographic Details
Main Authors: Grazia eMaugeri, Agata Grazia eD'Amico, Rita eReitano, Gaetano eMagro, Sebastiano eCavallaro, Salvatore eSalomone, Velia eD'Agata
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-05-01
Series:Frontiers in Pharmacology
Subjects:
VIP
EGFR
hypoxia
PACAP
HIFs
glioblastoma multiforme invasiveness
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00139/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00139/full

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