Combined targeting of GPX4 and BCR-ABL tyrosine kinase selectively compromises BCR-ABL+ leukemia stem cells

Combined targeting of GPX4 and BCR-ABL tyrosine kinase selectively compromises BCR-ABL+ leukemia stem cells

Abstract Background In the ongoing battle against BCR-ABL+ leukemia, despite significant advances with tyrosine kinase inhibitors (TKIs), the persistent challenges of drug resistance and the enduring presence of leukemic stem cells (LSCs) remain formidable barriers to achieving a cure. Methods In th...

Celý popis

Podrobná bibliografie
Hlavní autoři: Chengwu Zeng, Dingrui Nie, Xianfeng Wang, Shuxin Zhong, Xiangbo Zeng, Xin Liu, Kangjie Qiu, Xueting Peng, Wenyi Zhang, Shengting Chen, Xianfeng Zha, Cunte Chen, Zhenhua Chen, Weizhang Wang, Yangqiu Li
Médium: Článek
Jazyk:English
Vydáno: BMC 2024-10-01
Edice:Molecular Cancer
Témata:
Ferroptosis
Disulfiram
BCR-ABL+ leukemia
GPX4
Tyrosine kinase inhibitor
On-line přístup:https://doi.org/10.1186/s12943-024-02162-0

Internet

https://doi.org/10.1186/s12943-024-02162-0

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