Targeting Receptor Tyrosine Kinase on Lymphatic Endothelial Cells for the Therapy of Colon Cancer Lymph Node Metastasis

Targeting Receptor Tyrosine Kinase on Lymphatic Endothelial Cells for the Therapy of Colon Cancer Lymph Node Metastasis

Oral treatment with the dual-receptor tyrosine kinase inhibitor AEE788 effectively reduces the number of peritumoral lymphatic vessels and the incidence of lymph node metastasis in nude mice with human HT29 colon cancer cells growing in the cecum. Whether inhibition of lymph node metastasis in colon...

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Bibliographic Details
Main Authors: Robert B. Rebhun, Robert R. Langley, Kenji Yokoi, Dominic Fan, Jeffrey E. Gershenwald, Isaiah J. Fidler
Format: Article
Language:English
Published: Elsevier 2006-09-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Lymphatic endothelial cells
lymph node metastasis
colon cancer
tyrosine kinase
lymphangiogenesis
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558606800990

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http://www.sciencedirect.com/science/article/pii/S1476558606800990

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