Production of Modified Nucleosides in a Continuous Enzyme Membrane Reactor

Production of Modified Nucleosides in a Continuous Enzyme Membrane Reactor

Nucleoside analogues are important compounds for the treatment of viral infections or cancers. While (chemo-)enzymatic synthesis is a valuable alternative to traditional chemical methods, the feasibility of such processes is lowered by the high production cost of the biocatalyst. As continuous enzym...

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Bibliographic Details
Main Authors: Isabel Thiele, Heba Yehia, Niels Krausch, Mario Birkholz, Mariano Nicolas Cruz Bournazou, Azis Boing Sitanggang, Matthias Kraume, Peter Neubauer, Anke Kurreck
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:International Journal of Molecular Sciences
Subjects:
continuous enzyme membrane reactor (EMR)
halogenated nucleosides
nucleoside analogues
PID controller
purine nucleoside phosphorylase (PNP)
pyrimidine nucleoside phosphorylase (PyNP)
Online Access:https://www.mdpi.com/1422-0067/24/7/6081

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https://www.mdpi.com/1422-0067/24/7/6081

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