The role of cellular traction forces in deciphering nuclear mechanics

Abstract Cellular forces exerted on the extracellular matrix (ECM) during adhesion and migration under physiological and pathological conditions regulate not only the overall cell morphology but also nuclear deformation. Nuclear deformation can alter gene expression, integrity of the nuclear envelop...

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Bibliographic Details
Main Authors: Rakesh Joshi, Seong-Beom Han, Won-Ki Cho, Dong-Hwee Kim
Format: Article
Language:English
Published: American Association for the Advancement of Science (AAAS) 2022-09-01
Series:Biomaterials Research
Subjects:
Online Access:https://doi.org/10.1186/s40824-022-00289-z