A Novel Calpain Inhibitor Compound Has Protective Effects on a Zebrafish Model of Spinocerebellar Ataxia Type 3

A Novel Calpain Inhibitor Compound Has Protective Effects on a Zebrafish Model of Spinocerebellar Ataxia Type 3

Spinocerebellar ataxia type 3 (SCA3) is a hereditary ataxia caused by inheritance of a mutated form of the human <i>ATXN3</i> gene containing an expanded CAG repeat region, encoding a human ataxin-3 protein with a long polyglutamine (polyQ) repeat region. Previous studies have demonstrat...

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Bibliographic Details
Main Authors: Katherine J. Robinson, Kristy Yuan, Stuart K. Plenderleith, Maxinne Watchon, Angela S. Laird
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Cells
Subjects:
calpain
spinocerebellar ataxia-3
Machado Joseph disease
polyglutamine
zebrafish
Online Access:https://www.mdpi.com/2073-4409/10/10/2592

Internet

https://www.mdpi.com/2073-4409/10/10/2592

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