Age and APOE affect L-carnitine system metabolites in the brain in the APOE-TR model

Age and APOE affect L-carnitine system metabolites in the brain in the APOE-TR model

With age the apolipoprotein E (APOE) E4 allele (involved in lipid homeostasis) is associated with perturbation of bioenergetics pathways in Alzheimer’s disease (AD). We therefore hypothesized that in aging mice APOE genotype would affect the L-carnitine system (central to lipid bioenergetics), in th...

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Bibliographic Details
Main Authors: Claire J. C. Huguenard, Adam Cseresznye, Teresa Darcey, Aurore Nkiliza, James E. Evans, Stanley L. Hazen, Michael Mullan, Fiona Crawford, Laila Abdullah
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Aging Neuroscience
Subjects:
apolipoproteins
fatty acid metabolism
lipid oxidation
vascular biology
Alzheimer’s disease
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2022.1059017/full

Internet

https://www.frontiersin.org/articles/10.3389/fnagi.2022.1059017/full

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