Head pleomorphic sarcoma showing murine double minute 2 amplification without a well‐differentiated liposarcoma component in a pediatric patient
Abstract Background Murine double minute 2 (MDM2) is an oncogene that inhibits p53, leading to decreased apoptosis. Sarcomas showing MDM2 amplification are rare among pediatric patients. Case A 14‐year‐old boy presented with pleomorphic sarcoma of the head showing MDM2 amplification without a well‐d...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-02-01
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| Series: | Cancer Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/cnr2.1774 |
| _version_ | 1797902738235850752 |
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| author | Mitsuko Akaihata Ikuko Takahashi Yuko Kakuda Takuya Kawata Takashi Mukaigawa Testuro Onitsuka Shigeyuki Murayama Yuji Ishida |
| author_facet | Mitsuko Akaihata Ikuko Takahashi Yuko Kakuda Takuya Kawata Takashi Mukaigawa Testuro Onitsuka Shigeyuki Murayama Yuji Ishida |
| author_sort | Mitsuko Akaihata |
| collection | DOAJ |
| description | Abstract Background Murine double minute 2 (MDM2) is an oncogene that inhibits p53, leading to decreased apoptosis. Sarcomas showing MDM2 amplification are rare among pediatric patients. Case A 14‐year‐old boy presented with pleomorphic sarcoma of the head showing MDM2 amplification without a well‐differentiated liposarcoma component. Although chemotherapy was initially performed to reduce the tumor size before surgery, the tumor did not shrink. The patient underwent complete surgical resection. Microscopic examination revealed a positive surgical margin; thus, postoperative proton‐beam radiotherapy was performed. 3 years after the therapy, no sign of recurrence was observed. Conclusion Macroscopic surgical resection combined with adjuvant postoperative radiotherapy was effective against MDM2‐amplified pleomorphic sarcoma refractory to neoadjuvant chemotherapy in a pediatric patient. |
| first_indexed | 2024-04-10T09:22:27Z |
| format | Article |
| id | doaj.art-be3d1543db384b7c9767bf721cd030d8 |
| institution | Directory Open Access Journal |
| issn | 2573-8348 |
| language | English |
| last_indexed | 2024-04-10T09:22:27Z |
| publishDate | 2023-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Reports |
| spelling | doaj.art-be3d1543db384b7c9767bf721cd030d82023-02-20T10:23:21ZengWileyCancer Reports2573-83482023-02-0162n/an/a10.1002/cnr2.1774Head pleomorphic sarcoma showing murine double minute 2 amplification without a well‐differentiated liposarcoma component in a pediatric patientMitsuko Akaihata0Ikuko Takahashi1Yuko Kakuda2Takuya Kawata3Takashi Mukaigawa4Testuro Onitsuka5Shigeyuki Murayama6Yuji Ishida7Division of Pediatrics Shizuoka Cancer Center Shizuoka JapanDivision of Pediatrics Shizuoka Cancer Center Shizuoka JapanDivision of Pathology Shizuoka Cancer Center Shizuoka JapanDivision of Pathology Shizuoka Cancer Center Shizuoka JapanDivision of Head and Neck Surgery Shizuoka Cancer Center Shizuoka JapanDivision of Head and Neck Surgery Shizuoka Cancer Center Shizuoka JapanRadiation and Proton Therapy Center Shizuoka Cancer Center Shizuoka JapanDivision of Pediatrics Shizuoka Cancer Center Shizuoka JapanAbstract Background Murine double minute 2 (MDM2) is an oncogene that inhibits p53, leading to decreased apoptosis. Sarcomas showing MDM2 amplification are rare among pediatric patients. Case A 14‐year‐old boy presented with pleomorphic sarcoma of the head showing MDM2 amplification without a well‐differentiated liposarcoma component. Although chemotherapy was initially performed to reduce the tumor size before surgery, the tumor did not shrink. The patient underwent complete surgical resection. Microscopic examination revealed a positive surgical margin; thus, postoperative proton‐beam radiotherapy was performed. 3 years after the therapy, no sign of recurrence was observed. Conclusion Macroscopic surgical resection combined with adjuvant postoperative radiotherapy was effective against MDM2‐amplified pleomorphic sarcoma refractory to neoadjuvant chemotherapy in a pediatric patient.https://doi.org/10.1002/cnr2.1774liposarcomaMDM2 amplificationpediatricpleomorphic sarcoma |
| spellingShingle | Mitsuko Akaihata Ikuko Takahashi Yuko Kakuda Takuya Kawata Takashi Mukaigawa Testuro Onitsuka Shigeyuki Murayama Yuji Ishida Head pleomorphic sarcoma showing murine double minute 2 amplification without a well‐differentiated liposarcoma component in a pediatric patient Cancer Reports liposarcoma MDM2 amplification pediatric pleomorphic sarcoma |
| title | Head pleomorphic sarcoma showing murine double minute 2 amplification without a well‐differentiated liposarcoma component in a pediatric patient |
| title_full | Head pleomorphic sarcoma showing murine double minute 2 amplification without a well‐differentiated liposarcoma component in a pediatric patient |
| title_fullStr | Head pleomorphic sarcoma showing murine double minute 2 amplification without a well‐differentiated liposarcoma component in a pediatric patient |
| title_full_unstemmed | Head pleomorphic sarcoma showing murine double minute 2 amplification without a well‐differentiated liposarcoma component in a pediatric patient |
| title_short | Head pleomorphic sarcoma showing murine double minute 2 amplification without a well‐differentiated liposarcoma component in a pediatric patient |
| title_sort | head pleomorphic sarcoma showing murine double minute 2 amplification without a well differentiated liposarcoma component in a pediatric patient |
| topic | liposarcoma MDM2 amplification pediatric pleomorphic sarcoma |
| url | https://doi.org/10.1002/cnr2.1774 |
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