Extracellular vesicles derived from neural EGFL-Like 1-modified mesenchymal stem cells improve acellular bone regeneration via the miR-25-5p-SMAD2 signaling axis

Extracellular vesicles derived from neural EGFL-Like 1-modified mesenchymal stem cells improve acellular bone regeneration via the miR-25-5p-SMAD2 signaling axis

Stem cell based transplants effectively regenerate tissues; however, limitations such as immune rejection and teratoma formation prevent their application. Extracellular vesicles (EVs)-mediated acellular tissue regeneration is a promising alternative to stem cell based transplants. Although neural E...

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Bibliographic Details
Main Authors: Yanhua Lan, Huizhi Xie, Qianrui Jin, Xiaomin Zhao, Yang Shi, Yanyan Zhou, Zihe Hu, Yi Ye, Xiaoyuan Huang, Yingjia Sun, Zhuo Chen, Zhijian Xie
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2022-11-01
Series:Bioactive Materials
Subjects:
Extracellular vesicles
Mesenchymal stem cells
Bone regeneration
Cell-free scaffolds
miRNAs
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X22000275

Internet

http://www.sciencedirect.com/science/article/pii/S2452199X22000275

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