Metformin improves lipid metabolism and reverses the Warburg effect in a canine model of chronic atrial fibrillation

Metformin improves lipid metabolism and reverses the Warburg effect in a canine model of chronic atrial fibrillation

Abstract Background Previous studies demonstrated impaired lipid metabolism and augmented aerobic glycolysis in AF. The authors aimed to investigate whether the use of metformin, an AMPK activator, could reverse this metabolic remodeling in chronic AF and to explore the underlying mechanisms. Method...

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Bibliographic Details
Main Authors: Yaozhong Liu, Fan Bai, Na Liu, Baojian Zhang, Fen Qin, Tao Tu, Biao Li, Jiayi Li, Yingxu Ma, Feifan Ouyang, Qiming Liu
Format: Article
Language:English
Published: BMC 2020-02-01
Series:BMC Cardiovascular Disorders
Subjects:
Atrial fibrillation
Metabolism
Metformin
Warburg effect
AMPK
Online Access:https://doi.org/10.1186/s12872-020-01359-7

Internet

https://doi.org/10.1186/s12872-020-01359-7

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