SAMase of Bacteriophage T3 Inactivates <named-content content-type="genus-species">Escherichia coli</named-content>’s Methionine <italic toggle="yes">S</italic>-Adenosyltransferase by Forming Heteropolymers

SAMase of Bacteriophage T3 Inactivates <named-content content-type="genus-species">Escherichia coli</named-content>’s Methionine <italic toggle="yes">S</italic>-Adenosyltransferase by Forming Heteropolymers

ABSTRACT S-Adenosylmethionine lyase (SAMase) of bacteriophage T3 degrades the intracellular SAM pools of the host Escherichia coli cells, thereby inactivating a crucial metabolite involved in a plethora of cellular functions, including DNA methylation. SAMase is the first viral protein expressed upo...

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Bibliographic Details
Main Authors: Hadas Simon-Baram, Daniel Kleiner, Fannia Shmulevich, Raz Zarivach, Ran Zalk, Huayuan Tang, Feng Ding, Shimon Bershtein
Format: Article
Language:English
Published: American Society for Microbiology 2021-08-01
Series:mBio
Subjects:
enzyme filamentation
metabolic regulation
virus-host interaction
cryo-EM
molecular dynamics (MD) simulations
bacteriophage T3
Online Access:https://journals.asm.org/doi/10.1128/mBio.01242-21

Internet

https://journals.asm.org/doi/10.1128/mBio.01242-21

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