Establishment of a high-throughput detection system for DNA demethylating agents

Establishment of a high-throughput detection system for DNA demethylating agents

Epigenetic alterations underlie various human disorders, including cancer, and this has resulted in the development of drugs targeting epigenetic alterations. Although DNA demethylating agents are one of the major epigenetic drugs, only two compounds—5-azacytidine (5-aza-CR, azacitidine) and 5-aza-2...

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Bibliographic Details
Main Authors: Eriko Okochi-Takada, Naoko Hattori, Akihiro Ito, Tohru Niwa, Mika Wakabayashi, Kana Kimura, Minoru Yoshida, Toshikazu Ushijima
Format: Article
Language:English
Published: Taylor & Francis Group 2018-02-01
Series:Epigenetics
Subjects:
epigenetics, dna methylation
dna demethylating agent
mammalian cells
luciferase
high-throughput screening
Online Access:http://dx.doi.org/10.1080/15592294.2016.1267887

Internet

http://dx.doi.org/10.1080/15592294.2016.1267887

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