Rejuvenating effects of young extracellular vesicles in aged rats and in cellular models of human senescence

Rejuvenating effects of young extracellular vesicles in aged rats and in cellular models of human senescence

Abstract Rejuvenation of an old organism was achieved in heterochronic parabiosis experiments, implicating different soluble factors in this effect. Extracellular vesicles (EVs) are the secretory effectors of many cells, including cardiosphere-derived cells (CDCs) with demonstrated anti-senescent ef...

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Bibliographic Details
Main Authors: Lilian Grigorian Shamagian, Russell G. Rogers, Kristin Luther, David Angert, Antonio Echavez, Weixin Liu, Ryan Middleton, Travis Antes, Jackelyn Valle, Mario Fourier, Liz Sanchez, Eva Jaghatspanyan, Javier Mariscal, Rui Zhang, Eduardo Marbán
Format: Article
Language:English
Published: Nature Portfolio 2023-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-39370-5

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https://doi.org/10.1038/s41598-023-39370-5

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