Flavonoids and fibrate modulate apoE4-induced processing of amyloid precursor protein in neuroblastoma cells

Flavonoids and fibrate modulate apoE4-induced processing of amyloid precursor protein in neuroblastoma cells

IntroductionApolipoprotein (apo) E4, being a major genetic risk factor for Alzheimer’s disease (AD), is actively involved in the proteolytic processing of amyloid precursor protein (APP) to amyloid β (Aβ) peptide, the principle constituent of amyloid plaques in Alzheimer Disease (AD) patients. ApoE4...

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Bibliographic Details
Main Authors: Viralkumar Davra, Kenza E. Benzeroual
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-12-01
Series:Frontiers in Neuroscience
Subjects:
flavonoids
diosmetin
naringenin
fibrates
APP
amyloid β
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2023.1245895/full

Internet

https://www.frontiersin.org/articles/10.3389/fnins.2023.1245895/full

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