Lead exposure disturbs ATP7B-mediated copper export from brain barrier cells by inhibiting XIAP-regulated COMMD1 protein degradation

Lead exposure disturbs ATP7B-mediated copper export from brain barrier cells by inhibiting XIAP-regulated COMMD1 protein degradation

The brain barrier is an important structure for metal ion homeostasis. According to studies, lead (Pb) exposure disrupts the transportation of copper (Cu) through the brain barrier, which may cause impairment of the nervous system; however, the specific mechanism is unknown. The previous studies sug...

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Bibliographic Details
Main Authors: Yang Liu, Zai-Hua Zhao, Tao Wang, Jin-Yu Yao, Wen-Qing Wei, Li-Hong Su, Shuang-Shuang Tan, Zi-Xuan Liu, Han Song, Jing-Yuan Chen, Wei Zheng, Wen-Jing Luo, Gang Zheng
Format: Article
Language:English
Published: Elsevier 2023-05-01
Series:Ecotoxicology and Environmental Safety
Subjects:
BBB
BCB
COMMD1
ATP7B
XIAP
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651323003652

Internet

http://www.sciencedirect.com/science/article/pii/S0147651323003652

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