Verteporfin-induced proteotoxicity impairs cell homeostasis and survival in neuroblastoma subtypes independent of YAP/TAZ expression

Verteporfin-induced proteotoxicity impairs cell homeostasis and survival in neuroblastoma subtypes independent of YAP/TAZ expression

Abstract Neuroblastoma (NB) is a highly aggressive extracranial solid tumor in children. Due to its heterogeneity, NB remains a therapeutic challenge. Several oncogenic factors, including the Hippo effectors YAP/TAZ, are associated with NB tumorigenesis. Verteporfin (VPF) is an FDA-approved drug sho...

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Bibliographic Details
Main Authors: Alexandra-Larisa Condurat, Sepideh Aminzadeh-Gohari, Mirjana Malnar, Nicole Schider, Leonie Opitz, Ria Thomas, Vishal Menon, Barbara Kofler, Jan Pruszak
Format: Article
Language:English
Published: Nature Portfolio 2023-03-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-29796-2

Internet

https://doi.org/10.1038/s41598-023-29796-2

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