Characterization of recent and minimally passaged Brazilian dengue viruses inducing robust infection in rhesus macaques.

Characterization of recent and minimally passaged Brazilian dengue viruses inducing robust infection in rhesus macaques.

The macaque is widely accepted as a suitable model for preclinical characterization of dengue vaccine candidates. However, the only vaccine for which both preclinical and clinical efficacy results were reported so far showed efficacy levels that were substantially different between macaques and huma...

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Bibliographic Details
Main Authors: Maria Beatriz Borges, Renato Sergio Marchevsky, Ygara S Mendes, Luiz Gustavo Mendes, Ana Claudia Duarte, Michael Cruz, Ana Maria Bispo de Filippis, Pedro Fernando C Vasconcelos, Marcos Freire, Akira Homma, Sally Mossman, Edith Lepine, Yannick Vanloubbeeck, Clarisse Lorin, Marie-Pierre Malice, Elena Caride, Lucile Warter
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5919018?pdf=render

Internet

http://europepmc.org/articles/PMC5919018?pdf=render

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