Systematic characterization of a non-transgenic Aβ 1–42 amyloidosis model: synaptic plasticity and memory deficits in female and male mice

Systematic characterization of a non-transgenic Aβ 1–42 amyloidosis model: synaptic plasticity and memory deficits in female and male mice

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Abstract Background The amyloid-β (Aβ) cascade is one of the most studied theories linked to AD. In multiple models, Aβ accumulation and dyshomeostasis have shown a key role in AD onset, leading to excitatory/inhibitory imbalance, the impairments of synaptic plasticity and oscillatory activity, and...

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Bibliographic Details
Main Authors: Raquel Jiménez-Herrera, Ana Contreras, Souhail Djebari, Jaime Mulero-Franco, Guillermo Iborra-Lázaro, Danko Jeremic, Juan Navarro-López, Lydia Jiménez-Díaz
Format: Article
Language:English
Published: BMC 2023-09-01
Series:Biology of Sex Differences
Subjects:
Alzheimer’s disease
Amyloid-β
Aβ 1–42
Spatial memory
LTP
Hippocampus
Online Access:https://doi.org/10.1186/s13293-023-00545-4

Internet

https://doi.org/10.1186/s13293-023-00545-4

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