Identification and Validation of Aspartic Acid Semialdehyde Dehydrogenase as a New Anti-Mycobacterium Tuberculosis Target

Identification and Validation of Aspartic Acid Semialdehyde Dehydrogenase as a New Anti-Mycobacterium Tuberculosis Target

Aspartic acid semialdehyde dehydrogenase (ASADH) lies at the first branch point in the essential aspartic acid biosynthetic pathway that is found in bacteria and plants but is absent from animals. Mutations in the asadh gene encoding ASADH produce an inactive enzyme, which is lethal. Therefore, in t...

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Bibliographic Details
Main Authors: Jianzhou Meng, Yanhui Yang, Chunling Xiao, Yan Guan, Xueqin Hao, Qi Deng, Zhongyang Lu
Format: Article
Language:English
Published: MDPI AG 2015-09-01
Series:International Journal of Molecular Sciences
Subjects:
aspartic acid semialdehyde dehydrogenase
Mycobacterium tuberculosis
pathogenicity
pristinamycin
promotor-replacement mutant
drug resistance
Online Access:http://www.mdpi.com/1422-0067/16/10/23572

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http://www.mdpi.com/1422-0067/16/10/23572

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