EZH2 Methyltransferase and H3K27 Methylation in Breast Cancer
<p>Histone modifications are thought to control the regulation of genetic programs in normal physiology and cancer. Methylation (mono-, di-, and tri-methylation) on histone H3 lysine (K) 27 induces transcriptional repression, and thereby participates in controlling gene expression patterns. En...
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| Format: | Article |
| Language: | English |
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Ivyspring International Publisher
2012-01-01
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| Series: | International Journal of Biological Sciences |
| Online Access: | http://www.biolsci.org/v08p0059.htm |
| _version_ | 1819209573516443648 |
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| author | Kyung Hyun Yoo, Lothar Hennighausen |
| author_facet | Kyung Hyun Yoo, Lothar Hennighausen |
| author_sort | Kyung Hyun Yoo, Lothar Hennighausen |
| collection | DOAJ |
| description | <p>Histone modifications are thought to control the regulation of genetic programs in normal physiology and cancer. Methylation (mono-, di-, and tri-methylation) on histone H3 lysine (K) 27 induces transcriptional repression, and thereby participates in controlling gene expression patterns. Enhancer of zeste (EZH) 2, a methyltransferase and component of the polycomb repressive complex 2 (PRC2), plays an essential role in the epigenetic maintenance of the H3K27me3 repressive chromatin mark. Abnormal EZH2 expression has been associated with various cancers including breast cancer. Here, we discuss the contribution of EZH2 and the PRC2 complex in controlling the H3K27 methylation status and subsequent consequences on genomic instability and the cell cycle in breast cancer cells. We also discuss distinct molecular mechanisms used by EZH2 to suppress BRCA1 functions.</p> |
| first_indexed | 2024-12-23T05:57:26Z |
| format | Article |
| id | doaj.art-be56e3c2c8b041c0af33a39e0f8b29d9 |
| institution | Directory Open Access Journal |
| issn | 1449-2288 |
| language | English |
| last_indexed | 2024-12-23T05:57:26Z |
| publishDate | 2012-01-01 |
| publisher | Ivyspring International Publisher |
| record_format | Article |
| series | International Journal of Biological Sciences |
| spelling | doaj.art-be56e3c2c8b041c0af33a39e0f8b29d92022-12-21T17:57:46ZengIvyspring International PublisherInternational Journal of Biological Sciences1449-22882012-01-01815965EZH2 Methyltransferase and H3K27 Methylation in Breast CancerKyung Hyun Yoo, Lothar Hennighausen<p>Histone modifications are thought to control the regulation of genetic programs in normal physiology and cancer. Methylation (mono-, di-, and tri-methylation) on histone H3 lysine (K) 27 induces transcriptional repression, and thereby participates in controlling gene expression patterns. Enhancer of zeste (EZH) 2, a methyltransferase and component of the polycomb repressive complex 2 (PRC2), plays an essential role in the epigenetic maintenance of the H3K27me3 repressive chromatin mark. Abnormal EZH2 expression has been associated with various cancers including breast cancer. Here, we discuss the contribution of EZH2 and the PRC2 complex in controlling the H3K27 methylation status and subsequent consequences on genomic instability and the cell cycle in breast cancer cells. We also discuss distinct molecular mechanisms used by EZH2 to suppress BRCA1 functions.</p>http://www.biolsci.org/v08p0059.htm |
| spellingShingle | Kyung Hyun Yoo, Lothar Hennighausen EZH2 Methyltransferase and H3K27 Methylation in Breast Cancer International Journal of Biological Sciences |
| title | EZH2 Methyltransferase and H3K27 Methylation in Breast Cancer |
| title_full | EZH2 Methyltransferase and H3K27 Methylation in Breast Cancer |
| title_fullStr | EZH2 Methyltransferase and H3K27 Methylation in Breast Cancer |
| title_full_unstemmed | EZH2 Methyltransferase and H3K27 Methylation in Breast Cancer |
| title_short | EZH2 Methyltransferase and H3K27 Methylation in Breast Cancer |
| title_sort | ezh2 methyltransferase and h3k27 methylation in breast cancer |
| url | http://www.biolsci.org/v08p0059.htm |
| work_keys_str_mv | AT kyunghyunyoolotharhennighausen ezh2methyltransferaseandh3k27methylationinbreastcancer |